Reed-Sternberg cells are most closely linked to which disease?

Reed-Sternberg cells are most closely linked to which disease?

• A. Hodgkin's Lymphoma
• B. Non-Hodgkin's Lymphoma
• C. Multiple Myeloma
• D. Acute lymphoblastic leukemia

Answer: (A)

Reed-Sternberg cells are the hallmark cell type of Hodgkin lymphoma. These are large, often binucleated B cells with prominent nucleoli that produce an owl‑eye appearance under the microscope. Their presence in a lymph node biopsy is a key diagnostic feature that distinguishes Hodgkin lymphoma from other lymphoid neoplasms. Non-Hodgkin lymphomas generally do not show Reed-Sternberg cells, while multiple myeloma involves malignant plasma cells in the bone marrow and acute lymphoblastic leukemia involves lymphoblasts in the marrow. So, the disease most closely linked to Reed-Sternberg cells is Hodgkin lymphoma.

Reed-Sternberg cells are the hallmark cell type of Hodgkin lymphoma. These are large, often binucleated B cells with prominent nucleoli that produce an owl‑eye appearance under the microscope. Their presence in a lymph node biopsy is a key diagnostic feature that distinguishes Hodgkin lymphoma from other lymphoid neoplasms. Non-Hodgkin lymphomas generally do not show Reed-Sternberg cells, while multiple myeloma involves malignant plasma cells in the bone marrow and acute lymphoblastic leukemia involves lymphoblasts in the marrow. So, the disease most closely linked to Reed-Sternberg cells is Hodgkin lymphoma.