Which statement about von Willebrand disease treatment is true?

Which statement about von Willebrand disease treatment is true?

• A. Desmopressin, administration of vWF and factor VIII concentrate, and antifibrinolytic agents.
• B. Aspirin is the primary treatment.
• C. Anticoagulation with warfarin is first-line.
• D. Vitamin K alone cures vWD.

Answer: (A)

Treatment for von Willebrand disease focuses on replacing or mobilizing von Willebrand factor and supporting hemostasis. Von Willebrand factor helps platelets stick to damaged vessels and also carries factor VIII in the circulation, so restoring it improves both platelet adhesion and FVIII levels. In many patients with mild disease, desmopressin (DDAVP) prompts the release of stored vWF and FVIII, boosting hemostasis without giving a full blood product. For more severe disease or when DDAVP isn’t effective or suitable, therapy uses von Willebrand factor–containing concentrates that also provide factor VIII. Antifibrinolytic drugs, such as tranexamic acid or ε-aminocaproic acid, help stabilize clots, especially for mucosal bleeding or dental procedures. Aspirin would worsen bleeding and is not used, anticoagulation like warfarin would increase bleeding risk and is not appropriate, and vitamin K alone does not correct vWF deficiency since it doesn't address the missing or dysfunctional von Willebrand factor.

Treatment for von Willebrand disease focuses on replacing or mobilizing von Willebrand factor and supporting hemostasis. Von Willebrand factor helps platelets stick to damaged vessels and also carries factor VIII in the circulation, so restoring it improves both platelet adhesion and FVIII levels. In many patients with mild disease, desmopressin (DDAVP) prompts the release of stored vWF and FVIII, boosting hemostasis without giving a full blood product. For more severe disease or when DDAVP isn’t effective or suitable, therapy uses von Willebrand factor–containing concentrates that also provide factor VIII. Antifibrinolytic drugs, such as tranexamic acid or ε-aminocaproic acid, help stabilize clots, especially for mucosal bleeding or dental procedures.

Aspirin would worsen bleeding and is not used, anticoagulation like warfarin would increase bleeding risk and is not appropriate, and vitamin K alone does not correct vWF deficiency since it doesn't address the missing or dysfunctional von Willebrand factor.